0 Cytomegalovirus (CMV)

Cytomegalovirus (CMV)
  • Periventricular Calcifications
  • Chorioretinitis
  • Convulsions

Asymptomatic CMV is leading cause of Sensoryneural hearing loss ( 7% cases of CMV infection )

Diagnosis : 
CMV is in all body secretions
Thus can be isolated - Urine and Saliva are best specimens for CMV culture

Antigen PP65 - PCR against this is used.
Typical "owl eye" inclusion indicating CMV infection of a lung pneumocyte

Treatment :
IV - Gancyclovir (Side effect - Bone marrow depression)
if resistant - Foscarnet

Image Source : http://en.wikipedia.org/wiki/File:Cytomegalovirus_01.jpg

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