0 Monday disease

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"Monday disease" is related to which drug?
a)Spironolactone
b)Digoxin
c)Nitroglycerin
d)Hydrochlorothiazide


ANSWER:
Ans-C Monday disease is a toxicity that happens to those who are exposed to Nitroglycerin or isosorbide dinitrate industrially, like who work in construction or demolition industries, mix concrete, do plaster, ect.
During the week, Monday to Friday, they are exposed to the vasodilating action, so they build up a tolerance. If they are off on Saturday and Sunday the tolerance is lost. So when they go back to work on Monday the tachycardia, hypotension, flusing and headache return, but a tolerance is built up again by the next day.


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