0 Contraindications of Indomethacin

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Q. Contraindications of Indomethacin include all except ?

a. Large IVH
b. Renal Failure
c. Hepatic Failure
d. NEC

ANSWER:

Ans : A (Large IVH)

C/I of Indomethacin are:

1. Renal Failure
2. Hepatic Failure
3. DIC
4. NEC

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0 NMS

AIIMS nov 2008

Q . All of the following drugs can cause Neuroleptic Malignant syndrome (NMS) except :

a. Amantadine
b. Domperidone
c. Haloperidol
d. Metoclopramide

ANSWER:

Ans is A (amantadine) not B...
Domperidone may cause NMS though rarely... BUT AMANTADINE NEVER CAUSES NMS (its withdrawal can cause)..
This question is given wrongly in many MCQ books.

0 Digoxin induced arrythmias

True for Digoxin induced arrythmias are All except
a. Biventricular Tachycardia
b. Paroxysmal Atrial Tachycardia with variable AV block
c. Ventricular Bigeminy
d. May be used to regularize atrial fibrillation.

ANSWER:

d. May be used to regularize atrial fibrillation.

0 Loop Diuretic

Q.Site of action of loop diuretics?
a.Na-K channel inhibition
b.Na-K-2Cl channel inhibition
c.decreases sodium retention
d.increases ADH

ANSWER:

Ans : B

0 Resistance to acyclovir

Q.Resistance to acyclovir is treated with?
a.foscarnet
b.valacyclovir
c.famcyclovir
d.gancyclovir

ANSWER:

Ans: A--Fosarnet

0 Lithium toxicity (aipg2011)

Q.Which of the following antihypertensive drugs is contraindicated in a patient on Lithium in order to prevent toxicity?
A. Diuretics
B. Beta blockers
C. Calcium channel blockers
D. Clonidine

ANSWER:

ans : A. diuretics

0 Monday disease

"Monday disease" is related to which drug?
a)Spironolactone
b)Digoxin
c)Nitroglycerin
d)Hydrochlorothiazide

ANSWER:

Ans-C Monday disease is a toxicity that happens to those who are exposed to Nitroglycerin or isosorbide dinitrate industrially, like who work in construction or demolition industries, mix concrete, do plaster, ect.
During the week, Monday to Friday, they are exposed to the vasodilating action, so they build up a tolerance. If they are off on Saturday and Sunday the tolerance is lost. So when they go back to work on Monday the tachycardia, hypotension, flusing and headache return, but a tolerance is built up again by the next day.

0 Halothane metabolism

Halothane metabolism causes formation of all the following except which?:

a.	Bromide
b.	Chloride
c.	Iodine
d.	Trichloroacetic acid

ANSWER:

answer: C
There is no iodine in halothane, which has the chemical structure: CF3CHCLBr.

0 Itegrase inhibitor

Which of the following is the itegrase inhibitor approved for treatment of HIV
a. Raltigravir
b. Lopinavir
c. Tipranavir
d. Fosamprenavir

ANSWER:

Ans: A
this is a new drug approved for the treatment of advanced HIV in combination with other anti-HIV durgs

0 Therapy of toxoplasmosis

Q.Which of the following is used in the therapy of toxoplasmosis?
a. Artensenuate
b. Ciprofloxacin

c. Pyrimethamine
d. Thiacetazone  

ANSWER:

Answer: C
Toxoplasma gondii is an obligate intracellular parasite. It is one of the most common human parasites in the world. Combination of pyrimethamine and a sulfonamide is effective against acute toxoplasmosis in immunocompetent adults. These 2 drugs work synergistically against the tachyzoite form of T gondii. As an alternative to sulphonamides, clindamycin may be beneficial when used in combination with pyrimethamine.

0 PROVENGE

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Q. PROVENGE is a vaccine treatment for which of the following cancer

a. hepatoma
b. multiple myeloma
c. prostate cancer
d. hodgkin lymphoma

ANSWER:

answer: C
Provenge (generic name sipuleucel-T) is an immunotherapy for prostate cancer manufactured by Dendreon. It received U.S. Food and Drug Administration (FDA) approval for use in the treatment of advanced prostate cancer patients on April 29, 2010. It is the first FDA approved drug in its class.

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