1 Chromosome 15

CHROMOSOME 15 :

• Albinism
• Angelman syndrome (Maternal deletion or Paternal Disomy)
• Prader willi syndrome (Paternal Deletion or Maternal Disomy)
• Tay Sachs disease.
• Marfan syndrome.
• Bloom syndrome. 

Point to note : 

Fibrillin gene 1 (FBN 1) - On chromosome 15 - Marfan's Syndrome.

Fibrillin gene 2 (FBN 2) - On chromosome 5 - Beals syndrome

---

Mnemonic :
Its usually confusing to remember Prader willi and Angelman , deletion or disomy , maternal or paternal.

So here is the way

Prader Willi -- is Paternal Deletion (or maternal uniparental disomy) and Angelman's is vice-a-versa.

---

2 Amyloidosis of spleen

---

Types of Amyloidosis of spleen

• Sago spleen 
• Lardaceous spleen

SoFt  LiPs
Sago spleen - Amyloid deposits in lymph Follicles
Lardaceous spleen - Amyloid deposits in the Red Pulp


Amyloid deposition in lymph follicles --" sago spleen“
Amyloid deposition in the red pulp--" lardaceous spleen"

---