2 Biphasic pattern on histology

“ Biphasic pattern” on histology is seen in which tumor:
a. Rhabdomyosarcoma
b. Synovial cell sarcoma
c. Osteosarcoma
d. Neurofibroma

ANSWER:

Correct Ans : B

Other biphasic tumors are Epithelioid sarcoma, Mesothelioma
Triphasic tumor is Wilms' tumor

Lets see why most people think osteosarcoma here--
Osteosarcoma shows Biphasic Pattern of "INCIDENCE" , its not the histology.
A biphasic pattern of incidence of osteosarcoma has been observed; peaks have been noted among adolescents (rapid growth of long bones) and in the elderly (secondary tumors arising in association with Paget disease or within previously irradiated tissue).

0 NK cell

Which of the following is ass. with NK cell
1)CD92
2)CD93
3)CD94
4)CD95

ANSWER:

Ans : 3 (CD94) It is a NK cell inhibitory receptor.

0 Hodgkin Disease of the chest

Regarding Hodgkin Disease of the chest:
1. parenchymal disease can be seen in the absence of hilar adenopathy
2. hilar adenopathy can be seen in the absence of mediastinal adenopathy
3. pleural involvement is rare
4. posterior mediastinal adenopathy is common

ANSWER:

answer is 3) Hodgkin Disease - Freundlich and Bragg p 352, and Dahnert.
Parenchymal disease is "invariably" subsequent to hilar adenopathy, in fact, if a patient with known Hodgkin has no mediastinal-hilar disease and a new pulmonary nodule appears, it should be presumed to be unrelated and another source should be sought. Hilar adenopathy in the absence of mediastinal adenopathy is rare. Pleural involvement is rare even in the presence of a lymphomatous effusion. Most patients with pleural disease will have contiguous pulmonary or chest wall disease. Lymphadenopathy is nearly always anterior, not posterior, particularly in Hodgkin.

0 Switch over from fetal to adult Hb

At what gestational age switch over from fetal to adult hb synthesis begins? 
a.30 weeks 
b.36 weeks 
c.7 days post natal 
d.3 weeks post natal

ANSWER:

Ans here is 30 wks and NOT 36wks... If 20 wks was in options then the ans would be 20 wks.... many MCQ books give the wrong answer to it....
CORRECT POINTS ARE ---
1.After the first 8 weeks of development, the fetus' primary form of hemoglobin switches from embryonic hemoglobin to fetal hemoglobin....
2.Fetal Hb to Adult Hb SWITCHOVER BEGINS at 20 wks Intrauterine...
3.Significant switch over to adult Hb at 30 wks Intrauterine...
4.Adult Hb levels attained at 7 months of LIFE...
CLICK IMAGE TO ENLARGE --> Wintrobe's Clinical Hematology, Volume 1 By John P. Greer, Maxwell Myer Wintrobe

0 Stain to visualise reticulocyte

Best stain to visualise reticulocyte?
1)giemsa
2)methylene blue
3)cresyl blue
4)leishman stain 

ANSWER:

Ans is 3
Both 2nd and 3rd can stain. But best is 3rd

0 AMYLOID

TRUE REGARDING AMYLOID IS

1) LENGHT IS 7.5nm
2) EM--BETA PLAEATED SHEET LIKE STRUCUTRE
3) THIOFLAVIN T MAY B USED FR STAINING
4) DEPOSIT FRST IN ZONA FASCULATA FIRST 

ANSWER:

Ans : 3
LENGTH OF AMYLOID IS --INDEFINITE DIAMETER----7.5 TO 10 NM
DEPOSIT FIRST SEEN IN (IN CASE OF ADRENAL)IN ---ZONA GLOMERULOSA

0 LAD-2

Which of following is not ass. with LEUCOCYTE ADHESION DEFECIENCY-2
1)neutrophilia
2)delayed separation of umblical cord
3)mental retardation
4)bombay blood group 

ANSWER:

Ans : 2
delayed separation of umblical cord is feature of LAD-1

3 TENNIS RACKET CELLS

Q. TENNIS RACKET CELLS are seen in

a. sarcoma botryoides
b. vaginal adenocarcinoma
c.leiomyoma uterus
d.seminoma

ANSWER:

Ans: A. sarcoma botryoides = Embryonal Rhabdomyosarcoma.
• An uncommon, highly malignant vaginal tumor consisting of embryonal rhabdomyoblasts in infants & children.

• The tumor cells are small, have oval nuclei, & have small protrusions of cytoplasm from one end (tennis-racket cells)

0 Michaelis-Gutmann bodies

Q. Michaelis-Gutmann bodies are seen in :
a. Calcifying epithilioma
b. Malakoplakia
c. Pulmonary alveolar microlithiasis
d. Nephrocalcinosis

ANSWER:

Ans: B. Malakoplakia
Michaelis-Gutmann bodies (M-G bodies) are concentrically layered basophilic inclusions found in the urinary tract. They are 2 to 10 μm in diameter, and are thought to represent remnants of phagosomes mineralized by iron and calcium deposits.
M-G bodies are a pathognomonic feature of malakoplakia, an inflammatory condition that affects the genitourinary tract.

0 Pawn ball megakaryocytes

Q. Pawn ball megakaryocytes are characteristic of:

1.myelodysplastic syndrome.
2.idiopathic trombocytopenic purpura.
3.thrombotic thrombocytopenic purpura.
4.chloramphenicol toxicity.

ANSWER:

Ans : 1. MDS(myelodysplastic syndrome)
These are very small megakaryocytes.
Normally Megakaryocytes are very large and never seen in P/S.

0 Hamodalysis associated amyloid

Q. Hamodalysis associated amyloid is deposited in
a. Synovium
b. Liver
c. Kidney
d. Tongue

ANSWER:

Ans: A.. Synovium.
The inability of both cuprophane dialysis
membranes to filter, and renal failure patients to catabolize
the plasma protein Beta-2 microglobulin, results in the accumulation
and subsequent conversion of this substance to
amyloid fibrils. Amyloid is deposited predominantly in the
musculoskeletal system in synovial, articular and periarticular
tissue, resulting in a variety of conditions.

0 AIIMS nov 2010 PATHO

1.onion bulb appearance in a nerve biopsy is in
a) CIDP
b) leprosy
c) amyloidosis
d) diabetes

ANSWER:

ans: A- CIDP

2.Oligodendrocyte inclusion charecteristic of?
a) polio
b) JE
c) PML
d) alzheimer

ANSWER:

ans: C- PML-pprogressive multifocal leukoencephalopathy

3.Pale infarct seen in all except?
a) kidney
b) spleen
c) heart
d) lung

ANSWER:

ans: D- lung

4.Not a mediator of inflammation
a) INF
b) MPO
c) TNF
d) PG

ANSWER:

ans: B-MPO

5.Renal histopathology of wegener's granulomatosis?
a) focal necrotizing glomerulonephritis (answer)

0 Thrombosis

---

Q.Which of the following does not predispose to thrombosis?
a. homocystinuria
b. Hypomagnesaemia
c. Paroxysmal nocturnal haemoglobinuria
d. Polycythaemia

ANSWER:

answer: B
The other three are associated with both arterial and venous thrombi.
Other important causes include antiphospholipid syndrome and oral contraceptive pill.
Important inherited conditions which lead to recurrent venous thromboses are
1.Factor 5 Leiden
2.Protein C
3.Protein S and
4.Antithrombin 3 deficiency.

---

MedicoNotebook - Founder : DrShiviMudgal , Co-Founder : DrAyushGoel