0 Neonatal Sepsis

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Neonatal Sepsis :

Clinical features of Sepsis and bacteremia.

  1. Lethargic
  2. Feeding difficulty
  3. Seizures


Early ( <72hrs )

Late ( >72 hrs )

Pneumonia more common
Septecemia , Meningitis is common , Pneumonia.
Therefore LP is done
Maternal Risk factors
Maternal fever <2wks
Maternal foul smelling liquor
Premature rupture of membrane
Maternal Pain abdomen
Chorioamnitis
Multiple Vaginal examinations in mother
Nosocomial
Organisms : E.Coli , Group B Sterptococcus

Klebsiella , Listeria , E.Coli
Treatment : Ampicillin + Gentamycin
3rd Generation cephalosporins
Cefotaxime + Amikacin


Overall MC organism - Klebsiella
2nd MC - Staphylococcus Aureus

Sepsis Screen for early diagnosis :
1. TLC : < 5000 /cumm (More Suggestive)
              > 5000 /cumm

2. Absolute Neutrophil count : <1500 / cumm

3. Peripheral Smear for band cells (immature neutrophil) & toxic granules : >20% of total neutrophils

  • Thus I / T : >0.2 (Immature / Total Neutrophil )


4. Micro ESR : >15 mm fall in 1st hour

5. CRP : +ve

6. LP : in Late onset sepsis

7. CxR

Antibiotics Course duration
Bacteremia : 10-14 days
Meningitis : 3wks
Arthritis ; Osteomyelitis : 4-6wks




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