0 Some Diseases and Anaesthesia

Porphyria :

Contraindicated drugs - 
  • Thiopentone
  • Etomidate
  • Pentazocine
DOC - Propofol

Myesthenia Gravis :
  • Increased sensitivity to NDMR
  • Resistance to DMR
  • Sevoflurane is inhalational agent of choice
  • Atracurium (1/10th normal dose) is Muscle relaxant of choice.
  • Risk of post-op Respiratory failure.

Dystrophia Myotonica:
  • Tendency of Obstructive sleep apnea
  • Sch is Contraindicated (as it causes prolonged contraction)
  • Rapid sequence induction with Propofol and Rocuronium is used.

Duchenne Muscular Dystrophy :
  • Abnormal response to Sch and Volatile agents
  • IV induction preferred
  • Hyperkalemia common
  • NDMR duration is prolonged.

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