0 Local Anaesthetics

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Local Anaesthetics :


ESTERS

AMIDES
Procaine
Chloroprocaine (shortest acting)
Tetracaine
Lidocaine
Mepivacaine
Prilocaine
Bupivacaine
Etidocaine
Dibucaine (Longest acting)
Metabolized by Pseudocholinesterase( Plasma)   (except Cocaine which is metabolized in liver)

Metabolized in Liver
Unstable

Stable
Metabolized to PABA – therefore Allergy

Low incidence of allergy

Mnemonic : EPPP
Bind to Alpha1 glycoprotein in plasma

More intense and longer lasting anaesthesia






MedicoNotebook - Founder : DrShiviMudgal , Co-Founder : DrAyushGoel

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