0 Halothane

Halothane :

  • Spontaneous oxidative decomposition retarded by - thymol preservative.
  • Smooth induction
  • Least decrease in Systemic vascular resistance.
  • Lowers CO by direct myocardial depression
  • Decrease HR
  • Enhances myocardial sensitivity to dysrhythmogenic effects of epinephrine. (therefore not given in Pheochromocytoma)
  • Reacts with metals in Vaporizers in presence of moisture.
  • Maximum reduction in total hepatic blood flow and portal vein flow.
  • Fast and shallow breathing
  • Severe depression of hypoxic ventilatory drive.
  • Potent Bronchodialator
  • Depresses mucociliary function (Remember : Ether maintains ciliary function)
  • Cerebro Vasodialator
  • Prior hyperventilation required (to prevent increase in ICT)
  • No Pain relief
  • Uterine relaxant (Therefore DOC for Manual removal of placena ) ; (can cause PPH)
  • Halothane hepatitis - Centrilobular necrosis (Inhalational agent of choice then is Sevoflurane)
  1. Malignant hyperthermia
  2. Liver Dysfunction
  3. Hypovolemia
  4. Intra crania mass
  5. Aortic Stenosis
  6. Pheochromocytoma
  7. with Aminophyline

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