Benzodiazepines increase the frequency of the chloride ion channel opening at the GABAA receptor (pharmacodynamics: This increases the potency of GABA).
Midazolam : Water Soluble , can be used as Anticonvulsant
It is the 1st drug to decrease seizures in ICU.
Awakening due to redistribution.
CVS : Minimal CVS depression.
Respiratory syatem : decrease Ventilatory response to CO2
- Diazepam : Retrograde Amnesia
- Midazolam : Anterograde Amnesia
They decrease MAC by 30%