1 C-KIT and GIST

Interestingly, tumors with mutations in exon 11 of c-Kit's juxtamembrane region are particularly sensitive to imatinib, whereas those with exon 9 mutations (extracellular domain) respond better to sunitinib than imatinib. In the future, primary therapy for GIST may be determined by the specific molecular defect in c-Kit.

Ref: Harrison's Principles of Internal Medicine, 18th Edition

1 comment:

  1. It seems this is something very new. No one even told us in coaching.


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